Book : Genentech The Beginnings Of Biotech (synthesis) -...

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In the fall of 1980, Genentech, Inc., a little-known California genetic engineering company, became the overnight darling of Wall Street, raising over $38 million in its initial public stock offering. Lacking marketed products or substantial profit, the firm nonetheless saw its share price escalate from $35 to $89 in the first few minutes of trading, at that point the largest gain in stock market history. Coming at a time of economic recession and declining technological competitiveness in the United States, the event provoked banner headlines and ignited a period of speculative frenzy over biotechnology as a revolutionary means for creating new and better kinds of pharmaceuticals, untold profit, and a possible solution to national economic malaise. Drawing from an unparalleled collection of interviews with early biotech players, Sally Smith Hughes offers the first book-length history of this pioneering company, depicting Genentech’s improbable creation, precarious youth, and ascent to immense prosperity. Hughes provides intimate portraits of the people significant to Genentech’s science and business, including cofounders Herbert Boyer and Robert Swanson, and in doing so sheds new light on how personality affects the growth of science. By placing Genentech’s founders, followers, opponents, victims, and beneficiaries in context, Hughes also demonstrates how science interacts with commercial and legal interests and university research, and with government regulation, venture capital, and commercial profits. Integrating the scientific, the corporate, the contextual, and the personal, Genentech tells the story of biotechnology as it is not often told, as a risky and improbable entrepreneurial venture that had to overcome a number of powerful forces working against it. Review “Hughes has crafted an engaging historical account of Genentech from its beginnings as a small laboratory at the University of California, San Francisco to the 2009 merger with Roche for 47 billion dollars. . . . [Her] account will appeal to a broad audience and is a must read for scholars interested in the history of biotechnology. Highly recommended.” -- J. A. Hewlett Choice“[A]n important addition to the history of biotech.” -- Phillip A. Sharp, Massachusetts Institute of Technology Nature Medicine“Over the past 20 years Sally Smith Hughes has done a great service to science studies by conducting in-depth oral-history interviews with prominent scientists, venture capitalists, corporate leaders, and attorneys in the history and business of early biotechnology. She drew on her unprecedented access to corporate records and a large number of actors and their oral histories to write Genentech, the first comprehensive account of the creation and early development of the Genentech Corporation.” -- Doogab Yi Chemical Heritage Magazine“The author skillfully reveals the practical, day-to-day, hands-on roles played by venture capitalists focused on fiscal gain and scientists focused on scientific breakthroughs. . . . [A] fascinating read.” -- Valerie McGurk Nursing Standard“[A]n eminently readable (and, for classes, eminently assignable) story . . . . Smith Hughes is one of the foremost oral historians of science today, and Genentech is filled with illuminating interview snippets woven artfully into a narrative that both engages and (somewhat surreptitiously) analyzes. . . . [F]or a case study that lays out in lively detail the ambiguities and exuberances of high-tech entrepreneurship, Smith Hughes’s Genentech surely ranks among the very best.” -- Cyrus C. M. Mody, Rice University Bulletin of the History of Medicine“[A] fascinating book, vividly recount[ing] the blood, sweat, and tears of the early days of ‘genetic engineers’ working at the bench, designing new biomolecules, and capitalizing their promises on Wall Street.” Social History of Medicine“Genentech: The Beginnings of Biotech paints a wonderfully detailed pict
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